Chemical Constituents from <i>Streptomyces</i> sp. YG-7 Collected from Yingge Ridge and the <i>α</i>-Glucosidase Inhibitory Activity
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Chinese Journal of Tropical Crops ›› 2019, Vol. 40 ›› Issue (7): 1428-1433.DOI: 10.3969/j.issn.1000-2561.2019.07.026

• Agricultural Product Processing, Preservation, Storage, Analysis and Detection • Previous Articles     Next Articles

Chemical Constituents from Streptomyces sp. YG-7 Collected from Yingge Ridge and the α-Glucosidase Inhibitory Activity

PAN Jieming1,2,CHEN Huiqin2,WANG Hao2,MEI Wenli2,CAI Caihong2,TAN Zhiqiong1,*(),DAI Haofu2,*()   

  1. 1. Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, Hainan 570228, China
    2. Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China
  • Received:2018-10-11 Revised:2019-01-09 Online:2019-07-25 Published:2019-08-01
  • Contact: TAN Zhiqiong,DAI Haofu


The α-glucosidase activities of secondary metabolites from Streptomyces sp. YG-7 actinomycetes isolated from the soils collected from the virgin tropical rainforest Yingge Ridge were investigated. Nine compounds were isolated and purified by various chromatographic techniques, and the structures were identified as (1) 2-acetamido-5- chlorobenzamide, (2) cyclo (L-Pro-L-Leu), (3) 3,6-dibenzylidene-2,5-piperazinedione, (4) albonoursin, (5) (3Z, 6S)-3-benzylidene-6-isobutylpiperazine-2,5-dione, (6) 3-hydroxy-2-methyl-4-pyrone, (7) isophthalic acid, (8) methyl 3-carbamoylbenzoate, and (9) 2,3-dihydroxypropyl hexadecanoate through a combined analysis of physicochemical properties and spectral data. Among them, compounds 1, 7 and 8 were new natural products, and compounds 1, 3-5, 7-8 exhibited significantly α-glucosidase inhibitory activity.

Key words: actinomycetes, Yingge Ridge, chemical constituent, α-glucosidase

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